Spectinomycin
Description:
Spectinomycin is an aminocyclitol antibiotic primarily used to treat infections caused by gram-negative bacteria, particularly Neisseria gonorrhoeae (gonorrhea). It inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.
Brand Names:
- Trobicin
- Spectrobid
- Spectracef
- Spetoral
- Actinospect
Available Forms & Strengths:
- Injection (Intramuscular):
- 2 g (as Spectinomycin hydrochloride)
- 4 g (as Spectinomycin dihydrochloride)
Uses:
- Treatment of uncomplicated gonorrhea (in penicillin or cephalosporin-resistant cases, or for individuals allergic to penicillin).
- Sometimes used off-label for other infections caused by gram-negative bacteria.
Side Effects:
- Common:
- Pain at the injection site
- Fever
- Nausea
- Dizziness
- Headache
- Serious:
- Rash or allergic reaction (anaphylaxis)
- Hypersensitivity reactions
- Abdominal pain
Dosage:
- For Gonorrhea (Uncomplicated):
- Adults: 2 g intramuscularly as a single dose.
- For pharyngeal infections, a dose of 4 g may be used.
Contraindications:
- Known hypersensitivity to spectinomycin or any of its components.
- Not recommended for children or in individuals with significant renal impairment.
Drug Interactions:
- Very limited due to its specific use; however, caution is advised when used with other nephrotoxic drugs.
- May interact with other antibiotics, affecting its efficacy.
Warnings:
- Should only be used in infections confirmed or strongly suspected to be caused by susceptible bacteria.
- Use in pregnancy is typically considered safe but should be discussed with a healthcare provider.
- Not effective against syphilis, chlamydia, or viral infections.
Disclaimer:
- This information is provided for educational purposes and should not replace professional medical advice. Always consult a healthcare provider before starting or stopping any medication.
