Cefpirome is a fourth-generation cephalosporin antibiotic used to treat a variety of bacterial infections. Here’s a detailed overview:
Description
Cefpirome is a broad-spectrum cephalosporin antibiotic that targets a wide range of Gram-positive and Gram-negative bacteria. It is particularly effective against bacteria that are resistant to earlier-generation cephalosporins.
Brand Names
- Cefrom
- Cefpirome (various generics)
- Cefurom
- Cefperazone
- Cefpiroxil (similar but not the same)
Available Forms & Strengths
- Injectable Form: Typically available in strengths of 1g and 2g.
- Intravenous (IV) or Intramuscular (IM) administration
Uses
- Infections: Used to treat severe infections including:
- Pneumonia
- Urinary tract infections
- Skin and soft tissue infections
- Intra-abdominal infections
- Sepsis
Side Effects
Common side effects may include:
- Nausea
- Vomiting
- Diarrhea
- Rash
- Allergic reactions
Serious side effects can include:
- Severe allergic reactions (anaphylaxis)
- Clostridium difficile-associated diarrhea
- Liver enzyme abnormalities
Dose
- Typical Adult Dose: 1-2 grams IV or IM every 8-12 hours, depending on the severity of the infection.
- Adjustment may be needed for patients with renal impairment.
Contraindications
- Allergy: Known hypersensitivity to cephalosporins or penicillins.
- Renal Impairment: Requires caution and dose adjustment in patients with renal dysfunction.
Drug Interactions
- Anticoagulants: May increase the risk of bleeding when used with anticoagulants like warfarin.
- Probenecid: Can increase cefpirome levels in the blood.
- Other Antibiotics: Potential for interactions with other antibiotics affecting bacterial flora.
Warnings
- Renal Function: Monitor renal function during treatment, especially in patients with preexisting renal conditions.
- Superinfection: Prolonged use may lead to secondary infections or overgrowth of non-susceptible organisms.
Doctor Advised
Always follow the specific instructions provided by your healthcare provider regarding the dosage and duration of cefpirome treatment, as well as any necessary precautions or monitoring.
