Ertapenem
Description:
Ertapenem is a broad-spectrum carbapenem antibiotic that is effective against a variety of Gram-positive and Gram-negative bacteria, including anaerobes. It inhibits bacterial cell wall synthesis, making it useful for treating various infections.
Brand Names:
- Invanz
Dosage Forms:
- Available as a powder for injection, typically in 1 g vials.
Uses:
- Treatment of complicated skin and skin structure infections.
- Complicated intra-abdominal infections.
- Community-acquired pneumonia.
- Acute pelvic infections.
- Uncomplicated urinary tract infections.
Dosage:
- Adults: 1 g IV or IM once daily, typically for 3 to 14 days depending on the type and severity of the infection.
- Children: Dosage is weight-based and should be determined by a healthcare provider.
Side Effects:
- Common: Nausea, vomiting, diarrhea, headache.
- Serious: Allergic reactions (anaphylaxis), seizures, Clostridium difficile-associated diarrhea.
Contraindications:
- Known hypersensitivity to ertapenem or other carbapenems.
- Caution in patients with a history of seizures or CNS disorders.
Drug Interactions:
- May reduce the effectiveness of valproic acid (increased risk of seizures).
- Caution when used with other nephrotoxic drugs (e.g., aminoglycosides).
Special Considerations:
- Monitor renal function in patients with pre-existing renal impairment.
- Use with caution during pregnancy and breastfeeding; assess risks and benefits.
- Not indicated for infections caused by methicillin-resistant Staphylococcus aureus (MRSA) or Pseudomonas aeruginosa.
Conclusion:
Ertapenem is a potent antibiotic for treating a variety of serious infections, particularly in hospitalized patients. Its broad-spectrum activity and once-daily dosing make it a practical choice in clinical settings. However, careful monitoring for side effects and potential drug interactions is crucial for patient safety.
