Cefpodoxime Proxetil is a broad-spectrum cephalosporin antibiotic used to treat various bacterial infections. Here’s a comprehensive overview:
Description:
Cefpodoxime Proxetil is a prodrug that gets converted into its active form, cefpodoxime, in the body. It inhibits bacterial cell wall synthesis, leading to bacterial cell death.
Brand Names:
- Vantin
- Cefpodoxime
- Podoxime
- Ospen (brand name in some regions)
- Cefodox
Forms & Strengths:
- Tablets: 100 mg, 200 mg
- Suspension: 50 mg/5 mL, 100 mg/5 mL
Uses:
- Acute bacterial sinusitis
- Acute bacterial exacerbations of chronic bronchitis
- Community-acquired pneumonia
- Uncomplicated urinary tract infections
- Pharyngitis/tonsillitis caused by Streptococcus pyogenes
Side Effects:
- Gastrointestinal issues (e.g., nausea, diarrhea)
- Allergic reactions (e.g., rash, itching)
- Headache
- Dizziness
- Possible fungal infections
Dose:
- Adults: Typically 200 mg twice daily for most infections. Dosage may vary based on the type and severity of the infection.
- Children: Dose depends on weight and type of infection; commonly 10 mg/kg twice daily.
Contraindications:
- Hypersensitivity to cephalosporins or penicillins
- Caution in patients with a history of severe gastrointestinal disease, such as colitis
Drug Interactions:
- Antacids and H2-receptor antagonists may reduce absorption
- May increase the risk of nephrotoxicity with other nephrotoxic drugs
- Possible interaction with blood thinners (e.g., warfarin) which may affect bleeding risk
Warnings:
- Use cautiously in patients with a history of gastrointestinal disease, particularly colitis
- May cause an overgrowth of non-susceptible organisms
- Renal impairment may require dose adjustment
Doctor Advised:
Always follow your doctor’s instructions regarding dosage and duration of therapy. Inform your healthcare provider of all other medications and medical conditions to avoid potential interactions and complications.
