Ofloxacin + Tinidazole is a combination antibiotic medication used to treat various infections, particularly those involving both aerobic and anaerobic bacteria. Here’s an overview:
Description
This combination contains:
- Ofloxacin: A fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV.
- Tinidazole: An antiprotozoal and antibacterial agent that disrupts DNA synthesis in susceptible organisms.
The combination provides broad-spectrum coverage, effective against a range of bacterial and protozoal infections.
Brand Names
- Tinoz
- Tinoz-O
- Oftin TZ
- Zoxan TZ
- Ofzole TZ
Available Forms & Strengths
- Tablets: Common strengths include 200 mg of Ofloxacin + 600 mg of Tinidazole per tablet.
Uses
- Pelvic Inflammatory Disease (PID)
- Urinary Tract Infections (UTIs)
- Abdominal Infections
- Gynecological Infections
- Bacterial Vaginosis
- Certain types of gastroenteritis
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Headache
- Dizziness
- Rash
Dose
- Typically: One tablet (200 mg Ofloxacin + 600 mg Tinidazole) taken once or twice daily, depending on the specific infection and physician’s recommendations.
Contraindications
- Allergy to Ofloxacin, Tinidazole, or other fluoroquinolones and nitroimidazoles.
- Pregnancy (use only if absolutely necessary; can cause harm to the fetus).
- Liver Disease: Severe liver impairment can affect metabolism of Tinidazole.
- Children: Use is generally not recommended for children under 18 years.
Warnings
- Tendon Damage: Risk of tendonitis or rupture, especially in older adults or those on corticosteroids.
- Neurological Effects: May cause seizures, dizziness, or peripheral neuropathy.
- Alcohol Consumption: Avoid alcohol during and shortly after treatment with Tinidazole due to possible disulfiram-like reactions.
- Photosensitivity: Increased risk of sunburn.
- QT Prolongation: Caution in patients with a history of heart arrhythmias.
Always consult a healthcare provider for detailed information tailored to individual health needs and conditions.
