Lomefloxacin is a fluoroquinolone antibiotic used to treat a range of bacterial infections. Here’s a comprehensive overview:
Description
Lomefloxacin is a synthetic broad-spectrum antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, essential for bacterial DNA replication and repair. It is effective against various Gram-negative and Gram-positive bacteria.
Brand Names
- Lomacin
- Lomeflox
- Lomexin
- Lomflox
- Lomeflo
Available Forms & Strengths
- Tablets: Typically available in 400 mg strength.
Uses
- Urinary Tract Infections (UTIs)
- Respiratory Tract Infections (e.g., bronchitis, pneumonia)
- Skin and Soft Tissue Infections
- Prostatitis
- Sinusitis
- Gastrointestinal Infections (e.g., enteritis)
Side Effects
- Nausea
- Diarrhea
- Headache
- Dizziness
- Rash
- Insomnia
Dose
- Typically: 400 mg once or twice daily, depending on the type and severity of the infection. Duration of therapy varies based on the infection being treated.
Contraindications
- Allergy to Lomefloxacin or other fluoroquinolones.
- Pregnancy: Use only if absolutely necessary due to potential risks to the fetus.
- Children: Generally not recommended for children under 18 years.
- Severe Liver Impairment: Caution is advised.
Warnings
- Tendon Damage: Risk of tendonitis or tendon rupture, especially in older adults and those taking corticosteroids.
- QT Prolongation: Can cause prolongation of the QT interval, potentially leading to arrhythmias.
- Neurological Effects: Risk of seizures, tremors, or hallucinations.
- Photosensitivity: Increased sensitivity to sunlight can lead to a higher risk of sunburn.
- Drug Interactions: May interact with medications such as anticoagulants and antidiabetic drugs.
Always consult a healthcare provider for personalized medical advice and dosage instructions.
